肠道菌群紊乱所致炎症反应与抑郁症

抑郁症是一种与炎症反应、神经免疫关系密切的神经精神疾病。微生物,尤其是肠道菌群,则与人类免疫调节机制形成、感染和炎症反应息息相关。研究已证实,肠道菌群在炎症性肠病、哮喘等自身免疫性疾病的发生发展过程中起了相当大的作用。这些探讨非感染性疾病与微生物的关系的研究和理论形成了卫生学假说,亦即"老朋友"假说。目前,很多研究正在运用卫生学假说的观念,探索肠道菌群与抑郁症发生、发展、预防和治疗之间的联系,并取得了一些进展。本文重点就肠道菌群失调是否能够促进抑郁症发生及其可能机制做一综述。

Intestinal Bacteria Flora Alternation Caused Immune InflammatoryResponses and Depression

Depression is a neuropsychiatric disorder, which is strongly associated with inflammatory and immune response.Microorganism, especially intestinal bacteria flora, plays an important role in human immunoregulation, infection and inflammation. Ithas been proved that intestinal bacteria flora plays an important role in the onset and development of immune diseases such asinflammatory bowel disease and asthma. Based on the studies of the relationship between noninfectious diseases and microorganism, thehygiene hypothesis, also called ''Old Friends'' hypothesis, was formed. Nowadays, many studies are using this hypothesis to explain theassociation between depression and intestinal bacteria flora. Thus, we focus on the possible microbial mechanisms of depression in thisreview.