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Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (GPI): An intracellular signalling system involved in the control of thyroid cell proliferation |
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| Authors: | Emmanuelle Petitfrere Herve Sartelet Denis Vivien Isabel Varela-Nieto Hassan Elbtaouri Laurent Martiny Bernard Haye |
| Affiliation: | aLaboratoire de Biochimie, UPRES-A CNRS, UFR Sciences de Reims, Moulin de la Housse, BP 1039, 51687 Reims cedex 2, France;bLaboratoire de Neurosciences, URA 1829 CNRS, Université de Caen, bvd. H.-Becquerel, BP 5098, 14043 Caen cedex, France;cInstituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas (CSIC), Arturo Duperier 4, 28029 Madrid, Spain |
| Abstract: | In porcine thyrocytes, TSH alone does not induce cell growth. Recently, it has been demonstrated that acute stimulation by TSH of porcine thyrocytes leads to release an inositolphosphate glycan (IPG) described as a putative second messenger for various growth factors in different cell types. IPG isolated from porcine thyrocytes induces proliferation of fibroblasts EGFR T17 and porcine thyrocytes. In porcine thyrocytes we have confirmed that cell growth requires the presence of both TSH and insulin. This effect is reproduced by 8-bromo cyclic AMP suggesting a mediation by intracellular cyclic AMP. Cooperative effects between 8-bromo cyclic AMP and IPG have also been evidenced and are in favour of a crosstalk between distinct signalling pathways. |
| Keywords: | inositolphosphate glycan proliferation thyrocytes |
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