Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens |
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| Authors: | Hatzakis Nikos S Smonou Ioulia |
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| Institution: | Department of Chemistry, University of Crete, Iraklion 71409, Crete, Greece. |
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| Abstract: | A new asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens has been found. Although alcohols are not the natural substrates for this enzyme, a high R enantioselectivity was observed. Stereochemical studies showed that variations in substrate structure lead to strong variations in enantioselectivity. The highest enantioselectivities are obtained when the beta-carbon of the secondary alcohol is tertiary or quaternary. |
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| Keywords: | Ferulic acid Feruloyl esterase Humicola insolens Transesterification Enantioselectivity Secondary alcohols |
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