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A novel application of metabolomics in vertebrate development |
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| Authors: | Shunsuke Hayashi Yutaka Tamaru Toshinobu Fujiwara Kunio Inoue Shingo Maegawa Eiichiro Fukusaki |
| Affiliation: | a Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan b Department of Life Sciences, Faculty of Bioresources, Mie University, Tsu 514-8507, Japan c Department of Biology, Graduate School of Science, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan d Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan e Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan f Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Yoshida-Honmachi, Sakyo, Kyoto 606-8501, Japan |
| Abstract: | Many studies have demonstrated the functions of individual genes associated with embryogenesis and have determined the genome sequences of several organisms. Despite the availability of enormous amount of genetic information, dynamic changes that occur during embryogenesis have not yet been completely understood. In order to understand the dynamic processes involved in embryogenesis, we employed the metabolomic approach. The results of our study indicated that there is a close correlation between metabolomes and developmental stages. Our method enables the identification of embryonic stages using metabolomes as “fingerprints.” In this manner, we could successfully predict embryonic development on the basis of metabolomic fingerprints. This is the first report describing a model for predicting vertebrate development by using metabolomics. |
| Keywords: | Metabolomics Zebrafish Development Fingerprinting PLS |
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