首页 | 本学科首页   官方微博 | 高级检索  
   检索      


A novel application of metabolomics in vertebrate development
Authors:Shunsuke Hayashi  Yutaka Tamaru  Toshinobu Fujiwara  Kunio Inoue  Shingo Maegawa  Eiichiro Fukusaki
Institution:a Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan
b Department of Life Sciences, Faculty of Bioresources, Mie University, Tsu 514-8507, Japan
c Department of Biology, Graduate School of Science, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan
d Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan
e Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
f Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Yoshida-Honmachi, Sakyo, Kyoto 606-8501, Japan
Abstract:Many studies have demonstrated the functions of individual genes associated with embryogenesis and have determined the genome sequences of several organisms. Despite the availability of enormous amount of genetic information, dynamic changes that occur during embryogenesis have not yet been completely understood. In order to understand the dynamic processes involved in embryogenesis, we employed the metabolomic approach. The results of our study indicated that there is a close correlation between metabolomes and developmental stages. Our method enables the identification of embryonic stages using metabolomes as “fingerprints.” In this manner, we could successfully predict embryonic development on the basis of metabolomic fingerprints. This is the first report describing a model for predicting vertebrate development by using metabolomics.
Keywords:Metabolomics  Zebrafish  Development  Fingerprinting  PLS
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号