Non-enzymatic hydrolysis of creatine ethyl ester |
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| Authors: | Nicholas S. Katseres |
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| Affiliation: | Department of Chemistry and Biochemistry, The University of Tulsa, 800 Tucker Drive, Tulsa, OK 74014, USA |
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| Abstract: | The rate of the non-enzymatic hydrolysis of creatine ethyl ester (CEE) was studied at 37 °C over the pH range of 1.6-7.0 using 1H NMR. The ester can be present in solution in three forms: the unprotonated form (CEE), the monoprotonated form (HCEE+), and the diprotonated form (H2CEE2+). The values of pKa1 and pKa2 of H2CEE2+ were found to be 2.30 and 5.25, respectively. The rate law is found to be Rate=-dCCEE/dt=k++[H2CEE2+][OH-]+k+[HCEE+][OH-]+k0[CEE][OH-] |
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| Keywords: | Creatine Creatine ethyl ester Ester hydrolysis Kinetics Nutritional supplements |
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