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Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
Authors:Michael J Ziller  Juan A Ortega  Katharina A Quinlan  David P Santos  Hongcang Gu  Eric J Martin  Christina Galonska  Ramona Pop  Susanne Maidl  Alba Di Pardo  Mei Huang  Herbert Y Meltzer  Andreas Gnirke  CJ Heckman  Alexander Meissner  Evangelos Kiskinis
Institution:1. Department of Translational Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany;2. The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;3. Department of Biomedical and Pharmaceutical Sciences, George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA;4. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany;6. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA;7. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;8. Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Abstract:
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  • Keywords:DNA methylation  motor neurons  DNMT3A  cell fate  ESCs  neurogenesis  epigenetics  spinal cord development
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