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YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Authors:Shiro Yui  Luca Azzolin  Martti Maimets  Marianne Terndrup Pedersen  Robert P. Fordham  Stine L. Hansen  Hjalte L. Larsen  Jordi Guiu  Mariana R.P. Alves  Carsten F. Rundsten  Jens V. Johansen  Yuan Li  Chris D. Madsen  Tetsuya Nakamura  Mamoru Watanabe  Ole H. Nielsen  Pawel J. Schweiger  Stefano Piccolo  Kim B. Jensen
Affiliation:1. BRIC – Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, Denmark;2. Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy;3. Wellcome – MRC Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK;4. Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark;5. Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, 223 81 Lund, Sweden;6. Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8519, Japan;7. Novo Nordisk Foundation Center for Stem Cell Research, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark
Abstract:
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  • Keywords:intestinal stem cells  reprogramming  regeneration  YAP/TAZ  mechano-sensing
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