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Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
Authors:Jianghong Man  Xingjiang Yu  Haidong Huang  Wenchao Zhou  Chaomei Xiang  Haohao Huang  Lucio Miele  Zhenggang Liu  Gurkan Bebek  Shideng Bao  Jennifer S Yu
Institution:1. Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE30, Cleveland, OH 44195, USA;2. National Center of Biomedical Analysis, Beijing 100850, China;3. Department of Genetics, Louisiana State University Health Sciences Center, Clinical Sciences Research Building, Room 657, 533 Bolivar Street, New Orleans, LA 70112, USA;4. Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA;5. Department of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University, 10900 Euclid Avenue, BRB 921, Cleveland, OH 44106, USA;6. Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA;7. Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, CA50, Cleveland, OH 44195, USA
Abstract:
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  • Keywords:Vasorin  Notch  Numb  glioma  glioblastoma  hypoxia  pseudohypoxia  HIF1  STAT3  glioma stem-like cells
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