GALNT14 Involves the Regulation of Multidrug Resistance in Breast Cancer Cells |
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Authors: | Jinshuai Shan Yang Liu Yukun Wang Yimiao Li Xiaochun Yu Chen Wu |
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Institution: | 2. Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, 1500 E. Duarte Rd, Duarte, California, 91010, USA |
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Abstract: | GALNT14 is a member of N-acetylgalactosaminyltransferase enzyme family and mediates breast cancer cell development. Here, we find that GALNT14 regulates multidrug resistance (MDR) in breast cancer. The expression of GALNT14 is associated with MDR in breast cancer. Higher level of GALNT14 facilitates MCF-7 cells to resist Adriamycin, whereas knockdown of GALNT14 sensitizes cells to Adriamycin. Moreover, the expression of GALNT14 associates with the expression of P-gp, the efflux pump localized on the cell membrane, which could be the underlying mechanism of how GALNT14 induces MDR. In-depth analysis shows that GALNT14 regulates the stability of P-gp. Finally, GALNT14 associates with higher level of P-gp in chemotherapy-resistant human breast cancer tissues. Taken together, our studies reveal a molecular mechanism in breast cancer MDR. |
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Keywords: | Address all correspondence to: Xiaochun Yu or Chen Wu College of Life Sciences Hebei University Baoding 071002 Hebei P R China |
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