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Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression
Authors:Xiuxing Wang  Briana C Prager  Qiulian Wu  Leo JY Kim  Ryan C Gimple  Yu Shi  Kailin Yang  Andrew R Morton  Wenchao Zhou  Zhe Zhu  Elisabeth Anne Adanma Obara  Tyler E Miller  Anne Song  Sisi Lai  Christopher G Hubert  Xun Jin  Zhi Huang  Xiaoguang Fang  Jeremy N Rich
Institution:1. Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, USA;2. Department of Pathology, Case Western Reserve University, Cleveland, OH, USA;3. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA;4. Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China, Chongqing, China;5. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA;6. Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA;7. Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark;8. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Abstract:
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  • Keywords:glioblastoma  cancer stem cell  neurotrophin  glioma stem cell  differentiated glioma cell  VGF  BDNF  NTRK2
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