首页 | 本学科首页   官方微博 | 高级检索  
   检索      


A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
Authors:Marcella Cesana  Michael H Guo  Davide Cacchiarelli  Lara Wahlster  Jessica Barragan  Sergei Doulatov  Linda T Vo  Beatrice Salvatori  Cole Trapnell  Kendell Clement  Patrick Cahan  Kaloyan M Tsanov  Patricia M Sousa  Barbara Tazon-Vega  Adriano Bolondi  Federico M Giorgi  Andrea Califano  John L Rinn  George Q Daley
Institution:1. Stem Cell Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA;2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA;3. Harvard Stem Cell Institute, Cambridge, MA 02138, USA;4. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USA;6. Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA;7. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;8. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA;9. Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics, Pozzuoli 80078, Italy;10. Department of Translational Medicine, University of Naples “Federico II”, Naples 80131, Italy;11. Division of Hematology, University of Washington, Seattle, WA 98195, USA;12. Department of Systems Biology, Columbia University, New York, NY 10032, USA;13. Department of Genome Sciences, University of Washington, Seattle, WA 98115, USA;14. Department of Biomedical Engineering, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;15. Departments of Biomedical Informatics, Biochemistry and Molecular Biophysics, JP Sulzberger Columbia Genome Center, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA;16. University of Colorado Boulder Biofrontiers, Boulder, CO 80301, USA;17. Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Abstract:
/><ol class=
  • Download high-res image (93KB)
  • Download full-size image
  • Keywords:human hematopoietic stem cells  RNA-seq  alternative splicing  HMGA2  SRSF1  CLK3
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号