|
|||||
|
|
Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists |
|
| Authors: | Kamenecka Theodore M Bonnefous Céline Govek Steven Vernier Jean-Michel Hutchinson John Chung Janice Reyes-Manalo Grace Anderson Jeffery J |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. kameneck@scripps.edu |
| Abstract: | Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small molecule mGlu5 antagonists. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |