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Toward the blood-borne miRNome of human diseases |
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| Authors: | Keller Andreas Leidinger Petra Bauer Andrea Elsharawy Abdou Haas Jan Backes Christina Wendschlag Anke Giese Nathalia Tjaden Christine Ott Katja Werner Jens Hackert Thilo Ruprecht Klemens Huwer Hanno Huebers Junko Jacobs Gunnar Rosenstiel Philip Dommisch Henrik Schaefer Arne Müller-Quernheim Joachim Wullich Bernd Keck Bastian Graf Norbert Reichrath Joerg Vogel Britta Nebel Almut Jager Sven U Staehler Peer Amarantos Ioannis Boisguerin Valesca Staehler Cord Beier Markus Scheffler Matthias Büchler Markus W Wischhusen Joerg Haeusler Sebastian F M Dietl Johannes Hofmann Sylvia Lenhof Hans-Peter |
| Affiliation: | Biomarker Discovery Center, Heidelberg, Germany. ack@bioinf.uni-sb.de |
| Abstract: | In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs. |
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