Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans |
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| Authors: | Victoria Guiliana Soraya Yadav Bhawna Hauhnar Lalremruata Jain Priyanka Bhatnagar Shilpi Komath Sneha Sudha |
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| Affiliation: | School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India. |
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| Abstract: | A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans. Depleting CaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, down-regulates ERG11, altering ergosterol levels and drug response. This effect is specific to CaGpi19p depletion and is not due to cell wall defects or GPI deficiency. Additionally, down-regulation of ERG11 down-regulates CaGPI19 and GPI biosynthesis. |
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