Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity |
| |
| Authors: | Chen Lu Hamrah Pedram Cursiefen Claus Zhang Qiang Pytowski Bronislaw Streilein J Wayne Dana M Reza |
| |
| Institution: | Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA. |
| |
| Abstract: | There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
