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Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology |
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| Authors: | Roger-Marc Nicoud Graldine Fuchs Philippe Adam Michel Bailly Ernst Küsters Firoz D Antia Robert Reuille Emil Schmid |
| Institution: | Roger-Marc Nicoud,Géraldine Fuchs,Philippe Adam,Michel Bailly,Ernst Küsters,Firoz D. Antia,Robert Reuille,Emil Schmid |
| Abstract: | The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. © 1993 Wiley-Liss, Inc. |
| Keywords: | simulated moving bed technology chiral separation cellulose triacetate preparative scale liquid chromatography racemic epoxide |