Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV-infected rhesus macaques: Implications for immunopathogenesis |
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Authors: | David J. Blackbourn Linda F. Chuang Keith F. Killam Ronald Y. Chuang |
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Abstract: | The ability of the CD8 + cells from simian immunodeficiency virus (SIV)-infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat-stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell-mediated cell killing may therefore account for DC4 + cell depletion in certain SIV-infected macaques. |
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Keywords: | CD8 + suppressor SIVmac infection target cell lysis Macaca mulatta |
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