High-Performance liquid chromatography (HPLC) chiral separations of guaifenesin,methocarbamol, and racemorphan |
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Authors: | Iulia Demian |
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Abstract: | HPLC chiral separations on silica gel coated with derivatized cellulose stationary phases are described. Most examples make use of the Chiralcel OD column from Daicel, Inc. With a judiciously chosen mobile phase, baseline separations of the enantiomers can be achieved. If those separations are used as a base for enantiomeric purity determination, detectable limits of 0.1% of the minor enantiomer are routinely accessible. Examples are given concerning separations of guaifenesin, methocarbamol, and racemorphan. © 1993 Wiley-Liss, Inc. |
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Keywords: | chiral HPLC Chiralcel OD Chiralcel OD-R guaifenesin methocarbamol dextromethorphan levomethorphan racemorphan |
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