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Direct high-performance liquid chromatography (HPLC) separation of etodolac enantiomers using chiral stationary phases |
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| Authors: | Salvatore Caccamese |
| Abstract: | The enantiomers of the antiinflammatory drug Etodolac were separated without derivatization on Chiralcel OD and Pirkle (R)-DNBPG columns. Enantiomeric purity can be determined in less than 10 min. Optimization of separation was evaluated using various concentrations of 2-propanol (doped with TFA) in hexane as the mobile phase. © 1993 Wiley-Liss, Inc. |
| Keywords: | etodolac enantiomers chiral phases antiinflammatory |