Cervical ripening and uterine contraction induced by prostaglandin E2-gel in pregnant Japanese monkeys (Macaca fuscata fuscata) |
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Authors: | Keiko Shimizu Masumi Nozaki Kiyoshi Oshima |
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Abstract: | Effects of intracervical administration of PGE2-gel were studied in pregnant Japanese monkeys (Macaca fuscata fuscata) near term. Administration of PGE2-gel induced cervical ripening and an increase in maternal plasma PGE2 but no change in PGF2α. Ultrastructural observations of the connective tissue of the cervix after PGE2-gel treatment revealed a decrease in the number of collagenous fibers. These results show that intracervical administration of PGE2-gel induces cervical ripening without induction of labor in the Japanese monkey. |
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Keywords: | prostaglandins cervix uterus collagenous fiber pregnant monkey |
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