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Stereoselective analysis of ketorolac in human plasma by high-performance liquid chromatography
Authors:
Peter J Hayball
Julie G Tamblyn
Yvonne Holden
Jan Wrobel
Abstract:
A high-performance liquid chromatographic (HPLC) analytical method is described for the quantification of the (R)- and (S)-enantiomers of ketorolac when present together in human plasma. The method involves derivatization with thionyl chloride/(S)-1-phenylethylamine and subsequent reversed-phase chromatography of the diastereomeric (S)-1-phenylethylamides of (R)- and (S)-ketorolac. The method is suitable for the analysis of large numbers of plasma samples and has been applied in this report to a pharmacokinetic study of ketorolac enantiomers upon intramuscular administration of racemic drug to a human subject. The limit of quantification for each enantiomer of ketorolac is 50 ng/ml (signal-to-noise ratio > 10). © 1993 Wiley-Liss, Inc.
Keywords:
ketorolac enantiomers
HPLC
plasma concentrations
nonnarcotic analgesic
nonopiate analgesic
diastereomers
nonsteroidal antiinflammatory drugs (NSAIDs)
stereoselective pharmacokinetics
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