Primate antibodies to components of the human immune system |
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Authors: | L. L gdberg,E. Kaplan,M. Drelich,E. Harfeldt,H. Gunn,P. Ehrlich,D. Dottavio,P. Lake,L.
stberg |
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Affiliation: | L. Lögdberg,E. Kaplan,M. Drelich,E. Harfeldt,H. Gunn,P. Ehrlich,D. Dottavio,P. Lake,L. Östberg |
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Abstract: | The feasibility to raise nonhuman primate antibodies against selected components of the human immune system was tested. The immunogens were whole cells (human T lymphocytes) or purified, recombinant human proteins (cytokines: TNFα or GM-CSF; soluble forms of cell surface antigens: sCD4 or sCD25). Significant immunizations, yielding functionally relevant antibodies, were readily achieved in rhesus monkeys, but, not surprisingly, may be less frequent in chimpanzees. The results suggest a general strategy for production of therapeutically useful MAB. |
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Keywords: | chimpanzee baboon rhesus monkey CD4, CD25, interleukin-2 receptor TNF: GM-CSF immunization |
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