(1) Molekulare Genetik, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg, D-37077 G?ttingen, Federal Republic of Germany;(2) Present address: Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Abstract:
Summary Vacuoles are ubiquitous organelles in the fungal and plant kingdoms. They serve a variety of functions and are important for
cell homeostasis. A constant turnover of proteins and membranes makes vacuoles dynamic organelles. Various transport pathways
share the vacuole as their joint destination. The trafficking pathways are regulated independently. In yeast cells many components
of the protein and membrane transport machinery are known. Recent years have seen much progress in our understanding of the
protein-sorting pathways and the biogenesis of this organelle. Improvements of our understanding of the vesicular transport
pathways and vacuolar membrane fusion are reviewed.