Estradiol 17 beta-dehydrogenase and estradiol binding in human mammary tumors. |
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Authors: | Y J Abul-Hajj R Iverson D T Kiang |
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Affiliation: | College of Pharmacy and Section of Medical Oncology, Department of Medicine University of Minnesota, Minneapolis, MN. 55444 U.S.A. |
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Abstract: | The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens. |
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