Influence of parental and developmental cadmium exposure on endocrine and reproductive function in Japanese medaka (Oryzias latipes) |
| |
Authors: | Foran Christy M Peterson Bethany N Benson William H |
| |
Institution: | Environmental Toxicology Research Program, The University of Mississippi, University, MS 38677, USA. cmforan@mail.wvu.edu |
| |
Abstract: | Cadmium (Cd) is a ubiquitous element and an important anthropogenic metal contaminant. A series of assays were modified or developed for Japanese medaka (Oryzias latipes), and used to compare the effects of Cd exposure on indicators of endocrine function in adult animals previously exposed in ovo or as hatchlings. Adults were raised either from eggs produced during a 2 week exposure to 0-10 microg/l Cd or from fry exposed for 2 weeks beginning 2 days after hatching. The reproductive capacity of the resulting adults was determined during a 2 week period during which half of the animals were re-exposed to Cd. Two week Cd exposure did not result in reproductive impairment despite producing some changes in circulating steroid concentration. In addition, 1 microg/l cadmium exposure in ovo elevated male hepatic vitellogenin (VTG) relative to controls. Hence, steroid parameters were a better biomarker of cadmium exposure than changes in VTG. However, reproductive impairment was not correlated to change in VTG or plasma steroids. |
| |
Keywords: | Cadmium Developmental Endocrine Medaka Transgenerational Reproductive Steroid Teleost |
本文献已被 ScienceDirect PubMed 等数据库收录! |