| 微生物源农用抗生素的研发与高产策略 |
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| 引用本文： | 崔佳佳,张雪洪.微生物源农用抗生素的研发与高产策略[J].生物工程学报,2021,37(3):1032-1041. |
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| 作者姓名： | 崔佳佳 张雪洪 |
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| 作者单位： | 上海交通大学 生命科学技术学院 微生物代谢国家重点实验室，上海 200240 |
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| 基金项目： | 国家自然科学基金 (No. 31670033)，国家重点研发计划 (No. 2019YFA0904300) 资助。 |
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| 摘 要： | 开发高效、低毒、低残留的绿色农药是农药研发的发展趋势，其中微生物源农药抗生素占据了重要地位。随着基因组学、代谢工程、高通量筛选等技术的发展，新型微生物源农用抗生素的研究进入了新的阶段。文中简要总结了近10年来研发的新型微生物源农用抗生素的种类、农用抗生素产生菌株的高产育种与发酵研究策略等，为未来农用抗生素的研发提供参考。
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| 关 键 词： | 微生物，农用抗生素，高产菌株，育种 |
| 收稿时间： | 2020/10/10 0:00:00 |
Development and high yield strategies of microbial-derived antibiotics in agriculture |
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| Jiajia Cui,Xuehong Zhang.Development and high yield strategies of microbial-derived antibiotics in agriculture[J].Chinese Journal of Biotechnology,2021,37(3):1032-1041. |
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| Authors: | Jiajia Cui Xuehong Zhang |
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| Institution: | State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | The development of high-efficiency, low-toxicity, and low-residue green pesticides is the main trend of pesticide research, and the microbial-derived antibiotics are one of the essential parts of green pesticides and play a significant role in agriculture. With the development of microbial genomics technology, metabolic engineering, high-throughput screening and other technologies, the research on new microbial-derived antibiotics has entered a new stage in agriculture. Here we briefly summarize the types of new microbial-derived antibiotics developed in agriculture over the past decade. We also introduce the research strategies for high-yield breeding and fermentation of antibiotic-producing strains in agriculture. This review may provide references for the future development of agricultural antibiotics. |
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| Keywords: | microorganism agricultural antibiotics high-producing strain breeding |
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