| 空肠弯曲菌Ⅵ型分泌系统研究进展 |
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| 引用本文： | 汪闻妍,任方哲,李凤鸣,臧筱琦,焦新安,黄金林.空肠弯曲菌Ⅵ型分泌系统研究进展[J].微生物学通报,2021,48(3):932-937. |
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| 作者姓名： | 汪闻妍 任方哲 李凤鸣 臧筱琦 焦新安 黄金林 |
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| 作者单位： | 1 扬州大学江苏省人兽共患病学重点实验室 江苏 扬州 225009;2 江苏高校动物重要疫病与人兽共患病防控协同创新中心 江苏 扬州 225009;3 农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室 江苏 扬州 225009;1 扬州大学江苏省人兽共患病学重点实验室 江苏 扬州 225009;3 农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室 江苏 扬州 225009 |
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| 基金项目： | 国家重点研发项目(2018YFD0500500)；国家自然科学基金(31872493) |
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| 摘 要： | Ⅵ型分泌系统(TypeⅥSecretion System,T6SS)是一种倒置于细胞膜上的类噬菌体样结构,能够输送效应蛋白并在定殖和生态位建立中发挥作用。近年来,在空肠弯曲菌(Campylobacter jejuni)中发现了T6SS同源基因且能够表达组装成结构完整的T6SS,但T6SS对空肠弯曲菌的毒力影响尚不清楚。本文就空肠弯曲菌T6SS结构组成、分布特征及效应功能等方面的研究进展进行综述,以期为进一步解析空肠弯曲菌毒力因子的调控机制提供新思路。
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| 关 键 词： | 空肠弯曲菌 Ⅵ型分泌系统 毒力 |
Type VI secretion system in Campylobacter jejuni: a review |
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| WANG Wenyan,REN Fangzhe,LI Fengming,ZANG Xiaoqi,JIAO Xinan,HUANG Jinlin.Type VI secretion system in Campylobacter jejuni: a review[J].Microbiology,2021,48(3):932-937. |
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| Authors: | WANG Wenyan REN Fangzhe LI Fengming ZANG Xiaoqi JIAO Xinan HUANG Jinlin |
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| Institution: | 1 Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu 225009, China;2 Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, Jiangsu 225009, China;3 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of China, Yangzhou, Jiangsu 225009, China; 1 Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu 225009, China;3 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of China, Yangzhou, Jiangsu 225009, China |
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| Abstract: | The type VI secretion system (T6SS) is a contractile secretion machinery with a needle-like structure, and capable of delivering effectors that can play a role in host colonization and niche establishment. In recent years, the presence of a functional T6SS in Campylobacter jejuni has been reported. However, the effect of T6SS to the virulence factors of C. jejuni were still unclear. This review provided the recent studies on T6SS of C. jejuni, including the structure components, prevalence, and function, which is to reveal the molecular mechanism for virulence factors of C. jejuni. |
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| Keywords: | Campylobacter jejuni type VI secretion system virulence |
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