氟化天然产物生物合成的研究进展

氟元素是一种具有特殊性质的卤素,含氟有机物可广泛应用于生物有机化学、药物化学和生物材料科学等领域。尽管C-F键的合成方法有所创新,但将氟元素掺入到结构复杂的生物活性分子中的方法较少,因此选择性的氟化仍极具挑战性。本文从自然界中氟化天然产物及氟化酶的发现、氟化天然产物的合成通路、氟化天然产物合成机制的意义、氟化酶的进化及氟化物的合成、氟化酶和氟化物的应用等方面进行综述,希望可以为氟化物的生物法合成领域提供信息参考,推进氟化物生物法合成的工业化进程。

Advances in biosynthesis of fluorinated products

Fluorine is a kind of halogen with special properties. Fluorine-containing organic substances can be widely used in bioorganic chemistry, medicinal chemistry, biomaterial science and other fields. Despite innovation of synthetic C-F bond forming methods, selective fluorination is still very challenging. Therefore, it is necessary to use fluorine biochemical methods to selectively introduce fluorine into molecules with diverse structures, but few methods can incorporate fluorine into bioactive molecules with complex structures. Therefore, we review here the discovery of fluorinated natural products and fluorinases in nature, the synthetic pathway of fluorinated natural products, the significance of fluorinated natural product synthesis mechanism, the evolution of fluorinases and the synthesis of fluoride, and the application of fluorinases and fluoride. This review will provide information for fluoride biosynthesis and promote the industrialization process of fluoride biosynthesis.