| 线粒体自噬在感染性疾病中的作用机制研究进展 |
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| 引用本文： | 夏瑀培,王诚谱,毛旭虎,李倩.线粒体自噬在感染性疾病中的作用机制研究进展[J].微生物学通报,2021,48(4):1340-1347. |
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| 作者姓名： | 夏瑀培 王诚谱 毛旭虎 李倩 |
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| 作者单位： | 1 陆军军医大学药学与检验医学系临床微生物与免疫学教研室 重庆 400038;2 陆军军医大学基础医学院学员一大队 重庆 400038 |
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| 基金项目： | 国家自然科学基金(31970135，81971907)；陆军军医大学青年培育项目(2020XQN06) |
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| 摘 要： | 线粒体自噬作为一种选择性自噬方式是近年研究的热点。细胞通过自噬机制选择性清除受损伤或不必需的线粒体,从而维持其功能稳态。近年来,越来越多的研究聚焦于病原体通过胁迫线粒体自噬在机体感染过程中调节先天免疫信号通路,从而影响感染性疾病的进程。本文分别从线粒体自噬在病毒、细菌和真菌感染性疾病中的作用机制研究进展进行综述,以期为感染性疾病的防治提供新的指导策略。
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| 关 键 词： | 线粒体自噬，感染性疾病，病原体 |
Mitophagy in infectious diseases: a review |
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| XIA Yupei,WANG Chengpu,MAO Xuhu,LI Qian.Mitophagy in infectious diseases: a review[J].Microbiology,2021,48(4):1340-1347. |
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| Authors: | XIA Yupei WANG Chengpu MAO Xuhu LI Qian |
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| Institution: | 1 Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University, Chongqing 400038, China;2 Battalion One of Basic Medical Science, Army Medical University, Chongqing 400038, China |
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| Abstract: | As a selective form of autophagy, mitophagy has recently been considered as a research focus. It has been reported that mitophagy has a critical role in eliminating damaged or excessive mitochondria to maintain the cellular homeostasis. In recent years, accumulating studies have focused on mitophagy hijacked by pathogens in regulating innate immune signaling pathways to manipulate the course of infectious diseases. This article reviews the progress of mitophagy in the infectious diseases caused by virus, bacteria and fungi, aiming at providing a new reference for further strategies of prevention and treatment of infectious diseases. |
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| Keywords: | mitophagy infectious diseases pathogens |
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