植物口服疫苗的研究进展

植物口服疫苗是通过转基因植物生产,通过口服的方式预防疾病的生物制品.作为一种新型疫苗,其研究开始于三十几年前.由于植物口服疫苗可以最大程度地降低传统疫苗的潜在风险,在疫苗生产中具有优势,因此拥有良好的商业生产前景.植物疫苗价格低廉,生产过程安全,可产生与注射疫苗相似效价效果,无论是在控制养殖业抗生素滥用的情况下作为替代...

Advances in research on oral plant vaccines

Plant oral vaccines are biological products produced by genetically modified plants, and are taken orally to prevent disease. As a new kind of vaccine, its research originated about 30 years ago. Plant oral vaccines can avoid the potential risks of traditional vaccines to the greatest extent, and have advantages in vaccine production with good commercial production prospects. The price of plant vaccine is low, and the production is safety and effective. It is very ideal vaccine to prevent and control the certain infectious diseases, so as alternative to the breeding of antibiotics abuse cases, and suit for the low economic development areas, where have poor sanitation. In this review, the production methods, candidate bioreactors, vaccine effectiveness, application scope and development prospect of plant oral vaccine are summarized. In addition, the application of oral plant-based vaccines in zoonoses caused by viruses, bacteria or parasites, and the application in human tumor prevention are also reviewed in detail. Although there are challenges with plant vaccines in the amount of exogenous gene expression, immune dose, and immunization pathway and so on, plant vaccines still open up a promising new field for traditional vaccinology.