鲍曼不动杆菌VI型分泌系统溶血素-联合调节蛋白研究进展

鲍曼不动杆菌是一种革兰氏阴性的非发酵致病菌,在医院环境中广泛存在,并且已经成为医院获得性感染的重要病原体之一。近年来,由于抗菌药物的广泛应用,导致多重耐药鲍曼不动杆菌引起的感染和暴发流行,给临床治疗带来了极大的挑战。有研究表明,细菌Ⅵ型分泌系统与细菌的致病性相关。本文综述了鲍曼不动杆菌Ⅵ型分泌系统及主要功能蛋白(溶血素-联合调节蛋白)的研究进展,以期为进一步研究鲍曼不动杆菌的致病机制提供基础。

Role of haemolysin-coregulated protein in Acinetobacter baumannii type VI secretion system: a review

Acinetobacter baumannii is Gram-negative non-fermentative pathogenic bacteria, which exists widely in the hospital environment and has become one of the important pathogens of hospital-acquired infection. Due to the widespread use of antibacterial drugs, the infections and outbreaks caused by multi-drug resistant Acinetobacter baumannii have brought great challenges. Recent research indicated that type VI secretion system (T6SS) might be related to the pathogenicity of bacteria. In this review, we summarized the research progress of T6SS and T6SS-related proteins (haemolysin-regulated protein, Hcp), which provided the basis for further investigation about pathogenesis of Acinetobacter baumannii.