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Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells |
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| Authors: | Mary Mohrin Justin Liu Jose Zavala&#x;Solorio Sakshi Bhargava John Maxwell Trumble Alyssa Brito Dorothy Hu Daniel Brooks Georgios Koukos Lama Alabdulaaly Jonathan S Paw Kayley Hake Ganesh Kolumam Mary L Bouxsein Roland Baron Yuliya Kutskova Adam Freund |
| Institution: | 1. Calico Life Sciences LLC, South San Francisco CA, USA ; 2. AbbVie Inc, Chicago IL, USA ; 3. Harvard School of Dental Medicine, Boston MA, USA ; 4. Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston MA, USA ; 5. Harvard Medical School, Boston MA, USA |
| Abstract: | |
| Keywords: | aging bone marrow collagen extracellular matrix hematopoiesis insulin/IGF‐ 1 signalling mesenchymal stem cells |