Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982–2011 |
| |
| Institution: | 1. Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, 2052, Australia;2. Faculty of Medicine and Health Science, Macquarie University, Sydney, NSW, 2109, Australia;3. Douglass Hanly Moir Pathology, Macquarie Park, NSW, 2113, Australia;4. Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, 2145, Australia;5. Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW, 2170, Australia;1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;3. Department of Gastroenterology & Hepatology, Bankstown-Lidcombe Hospital, South Western Sydney Local Health Network, Sydney, New South Wales 2200, Australia;1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;1. Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA;2. Department of Medicine, Baylor College of Medicine, Houston, TX, USA;3. Houston Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA;4. Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA;5. Department of Biostatistics, University of Texas School of Public Health, Houston, TX, USA;1. Department of Epidemiology, University of Alabama at Birmingham, Birmingham Alabama, USA;2. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham Alabama, USA;3. Rocky Mountain Cancer Rehabilitation Institute, School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA;4. School of Social Work, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, USA;1. Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States;2. Center for Collaboration on Research Design and Analysis, University of Nebraska Medical Center, Omaha, NE, United States;3. Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center and Nebraska Methodist Hospital, Omaha, NE, United States;4. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States;5. College of Nursing, University of Nebraska Medical Center, Omaha, NE, United States;1. Department of Oral Medicineand Oral Pathology, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece;2. Laboratory of Biological Chemistry, School of Medicine, Aristotle University, 54124 Thessaloniki, Greece;3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece;1. Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD 21205, United States;2. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;3. Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, NY 11219, United States;4. University of Pittsburgh, 3520 Fifth Avenue, Pittsburgh, PA 15213, United States;5. University of California, Los Angeles, 2-256 Factor Bldg., Los Angeles, CA 90095-1702, United States;6. Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, United States;7. Northwestern University, 645 N Michigan Ave., Chicago, IL 60611, United States;8. CORE Center at John H. Stroger Jr. Hospital of Cook County, 2225 W Harrison St., Chicago, IL 60612, United States;9. Ohio State University Comprehensive Cancer Center, 420 W 12th Ave., Columbus, OH 43210, United States |
| |
| Abstract: | PurposeGerm cell tumour (GCT) aetiology is uncertain and comprehensive epidemiological studies of GCT incidence are few.MethodsNationwide data on all malignant GCTs notified to Australian population-based cancer registries during 1982–2011 were obtained. Age- and sex-specific, and World age-standardised incidence rates were calculated for paediatric (0–14) and adult (15+) cases using the latest WHO subtype classification scheme. Temporal trends were examined using Joinpoint regression.ResultsThere were 17,279 GCTs (552 paediatric, 16,727 adult). Age-specific incidence in males (all histologies combined) was bimodal, with peaks during infancy for most sites, and second, larger, peaks during young adulthood. Incidence of ovarian tumours peaked at age 15–19. Around half of paediatric tumours were extragonadal, whereas adult tumours were mostly gonadal. Yolk sac tumours and teratomas predominated in infants, whereas germinomas became more frequent towards adulthood. Increasing incidence trends for some adult gonadal tumours have stabilised; the trend for male extragonadal tumours is also declining.ConclusionBroad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures. |
| |
| Keywords: | Germ cell neoplasms Testicular neoplasms Ovarian neoplasms Incidence Australia |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
