Risk factors associated with human papillomavirus prevalence and cervical neoplasia among Cameroonian women |
| |
| Affiliation: | 1. College of Nursing, University of Utah, 10 S 2000 E, Salt Lake City, UT 84112, USA;2. Cancer Control and Population Sciences Department, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA;3. Study Design and Biostatistics Center, School of Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84132, USA;4. Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT, USA;5. Department of Internal Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT, USA;6. Department of Pharmacology and Toxicology, University of Utah, 30 N 1900 E, Salt Lake City, UT, USA;1. Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China;2. Department of Gynecology and Obstetrics, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China;3. Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China |
| |
| Abstract: | BackgroundThis study used community-based cervical cancer screening for high-risk human-papillomavirus (HPV) to determine demographic and lifestyle factors associated with HPV prevalence and cervical intraepithelial neoplasia grade 2 or worse (CIN2+).MethodsWomen (n = 838) aged 25–65 years were recruited in two sequential studies in Cameroon. Demographic and historical data were obtained from participants and specimens were self-collected for HPV-testing using real-time PCR. HPV-positive women underwent biopsy and endocervical curettage. Associations were determined using bivariate analysis and logistic regression.ResultsHPV and self-reported HIV prevalence were 39.0% and 9.2%, respectively. Eighteen (9.3%) CIN2+ lesions were found among HPV-positive women. Housewives had a higher risk of being HPV infected (OR = 1.60, p = 0.010). HIV co-infection (aOR = 3.44, p < 0.001) and hormonal contraception (aOR = 1.97, p = 0.007) were associated with increased HPV prevalence. HPV-positive women who used condoms during sexual intercourse were at lower risk of CIN2+ (aOR = 0.15, p = 0.029). CIN2–3 lesions were found in women younger than 50 years, with a median age of 36 years (31–44). HPV-16/18-positive women had a 4.65-fold increased risk of CIN2+ (p = 0.015).ConclusionsYoung, single women and housewives were at higher risk of HPV infection. Preventive strategies for cervical cancer in low-resource settings should target women aged 30–50 years for HPV screening, and should focus treatment and follow-up on HPV-16/18-positive women. Further studies are needed to clarify if other risk factors require attention. |
| |
| Keywords: | Cameroon Cervical cancer Human papillomavirus Risk factors |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
