Reduced incidence of skin cancer in patients with alopecia areata: A retrospective cohort study |
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| Affiliation: | 1. Department of Dermatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States;2. Department of Biostatistics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States;1. Acute and Communicable Disease Prevention Program, Oregon Public Health Division, Portland, Oregon, United States;2. Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, United States;1. Dermatology Unit, University of Campania, Vanvitelli, Naples, Italy;2. Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy;3. Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale–Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, Italy;1. Department of Dermatology, University of California Irvine, Irvine, California;2. Departments of Dermatology and Genetics and Development, Columbia University, New York, New York;3. Department of Dermatology, Cleveland Clinic, Cleveland, Ohio;4. Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas;5. National Alopecia Areata Foundation, San Rafael, California;6. Department of Dermatology, University of California San Francisco, San Francisco, California;7. Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts;8. Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota;9. Department of Dermatology, Yale School of Medicine, New Haven, Connecticut;10. Department of Dermatology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina;11. Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado;12. The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York;1. Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY;2. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY;3. Department of Genetics and Genomics Science, Icahn School of Medicine at Mount Sinai, New York, NY;6. Department of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY;4. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY;5. Laboratory for Investigative Dermatology, Rockefeller University, New York, NY;7. Department of Dermatology, Tel-Hashomer, Tel Aviv, Israel |
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| Abstract: | The risk of skin cancer in patients with alopecia areata (AA) is unknown. While the risk of skin cancer in chronic inflammatory alopecias may be elevated, AA shares many characteristics with vitiligo, an autoimmune illness associated with decreased risk of melanoma and non-melanoma skin cancers. In this retrospective cohort study, we determined the risk of developing skin cancer among patients with AA in a validated cohort relative to matched controls at two tertiary care hospitals in Massachusetts. There was a significantly decreased risk of NMSC in AA patients than controls (OR = 0.63, 95% CI = 0.48–0.81). There was a trend towards a protective effect of AA associated with melanoma (OR = 0.65, 95% CI = 0.39–1.09). There was no difference in anatomic distribution of skin cancer between patients with AA and controls. Our study demonstrates a decreased risk of nonmelanoma skin cancer and a trend towards reduced risk of melanoma in patients with AA. |
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| Keywords: | Alopecia areata Melanoma Non-melanoma skin cancer Basal cell carcinoma Squamous cell carcinoma Vitiligo Melanocytes Autoimmunity Epidemiology |
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