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The incidence and histo-pathological characteristics of colorectal cancer in a population based cancer registry in Zimbabwe
Institution:1. Department of Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe;2. Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape Town, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa;3. Zimbabwe National Cancer Registry, P.O. Box A449, Avondale, Harare, Zimbabwe,;4. Department of Community Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe;5. National Institute of Health Research, Cnr Mazowe/Josiah Tongogara street, Harare, Zimbabwe;6. MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa;1. Department of Cancer Epidemiology–Oncological Research Center of Santa Catarina (CEPON/SC), Brazil;2. Department of Public Health–Post-graduation Program, Federal University of Santa Catarina (UFSC), Brazil;1. Cancer Surveillance Group, Instituto Nacional de Cancerología, Bogotá, Colombia;2. Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia;3. Manizales Cancer Registry, Universidad de Caldas, Manizales, Colombia;4. Cali Cancer Registry, Universidad del Valle, Cali, Colombia;5. Barranquilla Cancer Registry, Universidad del Norte, Barranquilla, Colombia;6. Metropolitan Area of Bucaramanga Cancer Registry, Universidad Autónoma de Bucaramanga, Floridablanca, Colombia;7. Pasto Cancer Registry, Universidad de Nariño, Pasto, Colombia;8. Cancer Surveillance Section, International Agency for Research on Cancer (IARC), Lyon, France;9. RTI International, Research Triangle Park, NC, USA;10. Centers for Disease Control and Prevention, DCPC, 4770 Buford Highway, NE, Mailstop K-76, Atlanta, GA, USA;1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;2. Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark;3. Department of Clinical Immunology, the Blood Bank, Rigshospitalet, University Hospital of Copenhagen, Denmark;4. Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark;5. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark;6. Stanford University School of Medicine, Stanford, CA, USA;7. Hematology Centre, Karolinska University Hospital, Stockholm, Sweden
Abstract:BackgroundData on colorectal cancer (CRC) in sub-Saharan Africa is mainly based on hospital series which suggest low incidence and frequent early onset cancers. This study characterises colorectal cancer in a population-based cancer registry in Zimbabwe.MethodsCases of CRC recorded by the Zimbabwe National Cancer Registry between 2003 and 2012 were analysed. Demographic and pathological characteristics were compared according to ethnicity and age. Trends in age standardised incidence rates (ASR) were determined.ResultsThere were 886 and 216 cases of CRC among black Africans and Caucasians respectively, and 26% of the black Africans were younger than 40 years. Signet ring cell carcinomas were more common among black Africans compared to Caucasians (4% vs 1%, p = 0.027). ASR increased by 1.9%/year and 3.9%/year among black African males and females respectively.ConclusionCRC incidence is rising among black Africans and has unique demographic and pathological characteristics.
Keywords:Colorectal neoplasms  Signet ring cell carcinoma  Mucinous adenocarcinoma  Incidence  Africa south of the Sahara  Zimbabwe
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