Associations of body mass index with cancer incidence among populations,genders, and menopausal status: A systematic review and meta-analysis |
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| Institution: | 1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;3. Department of Gastroenterology & Hepatology, Bankstown-Lidcombe Hospital, South Western Sydney Local Health Network, Sydney, New South Wales 2200, Australia;1. Sam Fayad Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, Sydney, New South Wales, 2170, Australia;2. South Western Sydney Clinical School, University of New South Wales, Liverpool, Sydney, New South Wales, 2170, Australia;1. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Department of Biostatistics, The University of Texas School of Public Health, Houston, TX;3. Department of Internal Medicine, University of Miami, Miami, FL;4. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium;2. Department of Pediatrics, University Hospital of Antwerp, Wilrijkstraat 10, Edegem, Belgium;1. Department of Medicine, Baylor College of Medicine, Houston, TX, USA;2. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael. E DeBakey VA Medical Center, Houston, TX, USA;3. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;4. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA;5. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA;6. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;7. Department of Cancer Biology, Department of GI Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA;8. Texas Medical Center Digestive Disease Center, Houston, TX, USA;9. Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX, USA;10. Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX, USA;11. Michael E. DeBakey VA Medical Center, Houston, TX, USA;1. Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland;2. Royal College of Surgeons in Ireland, Dublin 2, Ireland;1. Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, China;2. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;3. Department of Health Service Management, Public Health School, Sun Yat-Sen University, Guangzhou, Guangdong, China;4. Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, China;5. The Comprehensive Guidance Center of Women''s Health, Chengdu Women''s and Children''s Central Hospital, Chengdu, China |
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| Abstract: | In order to further reveal the differences of association between body mass index (BMI) and cancer incidence across populations, genders, and menopausal status, we performed comprehensive meta-analysis with eligible citations. The risk ratio (RR) of incidence at 10 different cancer sites (per 5 kg/m2 increase in BMI) were quantified separately by employing generalized least-squares to estimate trends, and combined by meta-analyses. We observed significantly stronger association between increased BMI and breast cancer incidence in the Asia⿿Pacific group (RR 1.18:1.11⿿1.26) than in European⿿Australian (1.05:1.00⿿1.09) and North-American group (1.06:1.03⿿1.08) (meta-regression p < 0.05). No association between increased BMI and pancreatic cancer incidence (0.94:0.71⿿1.24) was shown in the Asia⿿Pacific group (meta-regression p < 0.05), whereas positive associations were found in other two groups. A significantly higher RR in men was found for colorectal cancer in comparison with women (meta-regression p < 0.05). Compared with postmenopausal women, premenopausal women displayed significantly higher RR for ovarian cancer (pre- vs. post- = 1.10 vs. 1.01, meta-regression p < 0.05), but lower RR for breast cancer (pre- vs. post- = 0.99 vs. 1.11, meta-regression p < 0.0001). Our results indicate that overweight or obesity is a strong risk factor of cancer incidence at several cancer sites. Genders, populations, and menopausal status are important factors effecting the association between obesity and cancer incidence for certain cancer types. |
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| Keywords: | Body mass index Obesity Cancer incidence Gender Population Meta-analysis |
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