The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles |
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| Authors: | Rickard Sandberg and Ingemar Ernberg |
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| Institution: | (1) Microbiology and Tumor Biology Center (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden;(2) Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA |
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| Abstract: | Background Cell lines as model systems of tumors and tissues are essential in molecular biology, although they only approximate the properties
of in vivo cells in tissues. Cell lines have been selected under in vitro conditions for a long period of time, affecting many specific cellular pathways and processes. |
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