内皮祖细胞(EPCs)研究进展

组织工程血管以及组织工程化组织的血管化因目前内皮种子细胞扩增能力和生物活力的不足而受到限制。EPCs(内皮祖细胞)是内皮细胞的前体细胞。在胚胎期,内皮细胞系与造血细胞系来源于血岛内共同的祖先细胞;出生后,EPCs存在于骨髓,并可被转移至外周血,参与缺血组织的血管重建和血管的内膜化。因此EPCs有望成为今后组织工程内皮种子细胞的重要来源。

Review on the Endothelial Progenitor Cells(EPCs)

The research on tissue engineered blood vessel and neovascularization of engineered tissue are limited by the shortage of endothelial seeding cells and its low bioactivity.EPCs (endothelial progenitor cells) are the precursors of mature endothelial cells in vivo.In embryo endothelial line and hematopoietic line originate from the common ancestor,hemangioblast,which differentiate in the blood island.Postnatal EPCs which normally exist in the bone marrow can be mobilized into peripheral blood and participate in vascular reconstruction in the ischemic tissue and endothelialization on the lumen of blood vessel.So maybe EPCs will become an ideal resource of endothelial seeding cells. ;