Salmochelin, the long-overlooked catecholate siderophore of Salmonella |
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Authors: | Silke I Müller Marianne Valdebenito Klaus Hantke |
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Institution: | 1. Lehrstuhl für Mikrobiologie – Organismische Interaktionen, Universit?t Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany
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Abstract: | Salmochelin is a C-glucosylated enterobactin produced by Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. It was the first glucosylated siderophore described. The glucosylation has been interpreted as a bacterial evasion
mechanism against the mammalian catecholate siderophore-binding protein siderocalin (NGAL-lipocalin). The synthesis, excretion,
and uptake of salmochelin requires five genes, iroBCDEN, and also the enterobactin biosynthesis and utilization system. Some salmochelin-producing strains also secrete microcins,
which possess a C-terminal, linear glucosyl-enterobactin moiety. These microcins recognize the catecholate siderophore receptors
IroN, Cir, Fiu, and FepA, and may inhibit the growth of competitors for catecholate siderophores. |
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Keywords: | Salmochelin Iron transport Siderocalin Salmonella C-glucosylation Microcin E492 |
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