Efficient synthesis of unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine |
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| Authors: | Ping-An Wang Wei He Si-Kun Cheng Sheng-Yong Zhang |
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| Institution: | 1. Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Changle Xilu 17, Xi’an, 710032, People’s Republic of China
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| Abstract: | The well-defined unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(?)-1-phenylethylamine, and phenylalanine. The configurations of all the chiral centers in these unnatural dipeptides are confirmed by X-ray crystal diffraction analysis. |
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