Design and synthesis of a fluorescent muscarinic antagonist |
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| Authors: | Jones Lyn H Randall Amy Napier Carolyn Trevethick Mike Sreckovic Sasha Watson Jessica |
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| Institution: | Discovery Chemistry, Sandwich Laboratories, Pfizer Research and Development, Ramsgate Rd, Kent CT2 8DR, UK. lyn.jones@pfizer.com |
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| Abstract: | The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high throughput screens. |
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