Nitrone derivatives of trolox as neuroprotective agents |
| |
Authors: | Balogh György T Vukics Krisztina Könczöl Arpád Kis-Varga Agnes Gere Anikó Fischer János |
| |
Institution: | Gedeon Richter Ltd, Budapest H-1475, 10. PO Box 27, Hungary. gy.balogh@richter.hu |
| |
Abstract: | Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe(2+)-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |