Appearance of dense granules in the rough endoplasmic reticulum of the juxtaglomerular cells in mice administered with captopril |
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| Authors: | Miho Kaneta Professor Kazuhiro Abe M.D. Ph.D. Takashi Ito |
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| Affiliation: | (1) Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan;(2) Department of Anatomy, Hokkaido University, School of Medicine, 060 Sapporo, Japan |
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| Abstract: | Summary Captopril [1-(D-3-mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)] is now known to be an inhibitor of angiotensin-converting enzyme. In male mice, the juxtaglomerular cells were examined by electron microscopy 42 h after administration of captopril. Numerous dense granules appeared in the rough endoplasmic reticulum of these cells. |
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| Keywords: | Juxtaglomerular cell Intracisternal granule Renin Angiotensin Captopril |
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