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Transhydrogenase activity in mammalian cells in vitro: Its possible physiological significance
Authors:C. De Luca  R. P. Gioeli
Affiliation:(1) Department of Oral Biology, School of Dentistry, State University of New York, 14226 New York, Buffalo
Abstract:Summary Transhydrogenase (NADH:NADP oxidoreductase, EC 1.6.1.1.) activity has been demonstrated in mammalian cells cultured in vitro. Levels of activity of this enzyme were 10- to 20-fold higher in H4-II-E-C3 cells derived from the minimal deviation Reuber hepatoma than in three other cell lines tested. H4 cells lack the abibility to reduce nicotinamide adenine dinucleotide phosphate by the glucose 6-phosphate dehydrogenase reaction. This raised the question of the physiological significance of transhydrogenase in these cells. This work was supported by Grant P513 from the American Cancer Society.
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