Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus |
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| Authors: | N. Hamaue A. Ogata M. Terado K. Ohno S. Kikuchi H. Sasaki K. Tashiro M. Hirafuji M. Minami |
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| Affiliation: | (1) Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Hokkaido, Japan;(2) Department of Molecular Bioscience, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Hokkaido, Japan;(3) Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Hokkaido, Japan;(4) Department of Clinical Physiology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Hokkaido, Japan;(5) School of Psychological Sciences, Health Sciences University of Hokkaido, Ainosato, Kita-ku, Sapporo 002-8072, Japan |
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| Abstract: | We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA) levels were significantly decreased in all JEV-infected rats. Norepinephrine concentration in brain regions in the 180-day group was significantly decreased in the medulla oblongata and hypothalamus as compared with the control and 90-day group. Tyrosine hydroxylase-positive neurons were significantly decreased in both JEV-infected rat groups. These results suggest that DA decrease and pathological changes in JEV-infected model rats persist for a long time, at least up to 180 days, and this model will be useful for the evaluation of new anti-parkinsonian agents. |
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| Keywords: | Parkinson disease Japanese encephalitis virus Striatum Dopamine Motor activity |
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