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Hinge Atlas: relating protein sequence to sites of structural flexibility |
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| Authors: | Samuel C Flores Long J Lu Julie Yang Nicholas Carriero Mark B Gerstein |
| Affiliation: | (1) Department of Physics, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT, USA;(2) Department of Molecular Biophysics and Biochemistry, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT, USA;(3) Department of Computer Science, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT, USA;(4) Computational Biology and Bioinformatics Program, Yale University, Bass 432, 266 Whitney Ave., New Haven, CT, USA |
| Abstract: | BackgroundRelating features of protein sequences to structural hinges is important for identifying domain boundaries, understanding structure-function relationships, and designing flexibility into proteins. Efforts in this field have been hampered by the lack of a proper dataset for studying characteristics of hinges. |
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