Crystal structures of Leptospira interrogans FAD-containing ferredoxin-NADP+ reductase and its complex with NADP+ |
| |
| Authors: | Alessandro S Nascimento Daniela L Catalano-Dupuy Amanda Bernardes Mario de Oliveira Neto Maria Auxiliadora M Santos Eduardo A Ceccarelli Igor Polikarpov |
| |
| Affiliation: | 1.Instituto de Física de S?o Carlos,Universidade de S?o Paulo,S?o Carlos,Brazil;2.Facultad de Ciencias Bioquímicas y Farmacéuticas, Molecular Biology Division,Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Universidad Nacional de Rosario,S2002LRK Rosario,Argentina |
| |
| Abstract: | Background Ferredoxin-NADP(H) reductases (FNRs) are flavoenzymes that catalyze the electron transfer between NADP(H) and the proteins ferredoxin or flavodoxin. A number of structural features distinguish plant and bacterial FNRs, one of which is the mode of the cofactor FAD binding. Leptospira interrogans is a spirochaete parasitic bacterium capable of infecting humans and mammals in general. Leptospira interrogans FNR (LepFNR) displays low sequence identity with plant (34% with Zea mays) and bacterial (31% with Escherichia coli) FNRs. However, LepFNR contains all consensus sequences that define the plastidic class FNRs. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
