Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release |
| |
| Authors: | Li Wang Jianmin Luo Shaoheng He |
| |
| Institution: | (1) The First Affiliated Hospital, Shantou University Medical College, Shantou, 515041, China;(2) Clinical Experiment Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China;(3) The Laboratory for Neural Repair, Shantou University Medical College, Shantou, 515041, China |
| |
| Abstract: | Background: It has been recognized that dermal fibroblasts and matrix metalloproteases (MMP) play crucial roles in wound healing process
in skin. Thrombin was found to stimulate IL-8 release from human dermal fibroblasts (HDFs). However, little is known of the
effect of thrombin on secretion of MMPs from dermal fibroblasts. In the present study, the influence of thrombin on proMMP-2
and proMMP-9 activity release from primary cultured HDFs, and its potential signaling pathways were investigated. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
